Botanical Drugs
Botanical Drugs

Botanical Drugs

is a peer-reviewed, open-access scientific journal aiming to provide a rigorous, open-access platform for original research, comprehensive reviews, and clinical evidence in the botanical drug industry. It covers broad areas to present the industry trend. The submission and Publication are free. Read more

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★ Editor's Pick
Review

CMC Challenges and Solutions in Botanical IND & NDA Development

Roger Luo
DOI View 2026
Original Research

Astragaloside A Attenuates Oxaliplatin-Induced Cardiotoxicity, Oxidative Stress, Apoptosis, and Calcium Overload in H9c2 Cardiomyoblasts

Ziheng He, Peng Cao, Wenyu Lin, Guoping Xu, Xueting Cai,...
DOI View
Original Research

Salidroside Improves Hyperuricemia by Simultaneously Regulating Uric Acid Production and Excretion

Shaoshi Zhang, Shun-Dan Li, Dong Chang, Ming‑Yue Wang,...
DOI View
Targeting Apoptotic Pathways in Cancer with Emodin: Intrinsic, Extrinsic, and Caspase-Independent Mechanisms
Review

Targeting Apoptotic Pathways in Cancer with Emodin: Intrinsic, Extrinsic, and Caspase-Independent Mechanisms

Gorky Guha, Shreya Das, Jhansi Kompala, Sohith Reddy Korlagunta, Sukant Khurana, Alfredo Ghezzi, Lakshminarayanan Karthik, Abhijit G Banerjee
Programmed cell death, also known as apoptosis, is crucial for maintaining cellular homeostasis and plays a significant role in tumor development, progression, and resistance to treatment. Evading apoptosis has been a characteristic of cancer, and apoptotic signaling pathways have been proposed as targets of anticancer drug development. Emodin, a naturally occurring anthraquinone produced by medicinal plants, has become a promising...
Jul 05, 2026
Full Article View
Astragaloside A Attenuates Oxaliplatin-Induced Cardiotoxicity, Oxidative Stress, Apoptosis, and Calcium Overload in H9c2 Cardiomyoblasts
Original Research

Astragaloside A Attenuates Oxaliplatin-Induced Cardiotoxicity, Oxidative Stress, Apoptosis, and Calcium Overload in H9c2 Cardiomyoblasts

Ziheng He, Peng Cao, Wenyu Lin, Guoping Xu, Xueting Cai, Qian Zhou, Yali Liu
Background: Oxaliplatin is a widely used platinum-based chemotherapeutic agent, and its cardiotoxicity remains an important safety concern during cancer treatment. Astragalus -derived saponins have been reported to exert cardioprotective effects; however, the specific active constituent responsible for protecting against oxaliplatin-induced myocardial injury has not been identified. Methods: Several Astragalus saponins and related...
May 15, 2026
Full Article Presentation Video View
Rhubarb-Centered Therapy for Intraductal Papillary Mucinous Neoplasm (IPMN): A Case Series and Integrative Medicine Exploration
Case Report

Rhubarb-Centered Therapy for Intraductal Papillary Mucinous Neoplasm (IPMN): A Case Series and Integrative Medicine Exploration

Fan Le, Yufang Xiao, Huifang Brown
Intraductal papillary mucinous neoplasm (IPMN) is an increasingly recognized pancreatic cystic tumor with variable malignant potential. Surgical resection remains the standard treatment for high-risk cases, whereas low-risk patients are typically managed with surveillance. This study presents two clinical cases treated with a rhubarb-centered therapeutic strategy. Both patients demonstrated symptomatic improvement and stable imaging findings....
Apr 15, 2026
Full Article View
Plant-Derived Exosome-Like Nanoparticles: Advances in Therapeutic Applications and Drug Delivery
Review

Plant-Derived Exosome-Like Nanoparticles: Advances in Therapeutic Applications and Drug Delivery

Lu Zhan, Xuqin Huang, Bowen Chang, Qian Li, Li Zhang, Songping Xie, Jie Huang
Background: Plant-derived exosome-like nanoparticles (PELNs) are nanoscale vesicles secreted by plant cells that contain lipids, proteins, RNAs, and secondary metabolites. Increasing evidence indicates that these vesicles can deliver plant-derived molecules into mammalian cells and modulate biological processes, including inflammation, oxidative stress, and immune responses. Scope of the Review: This review summarizes current knowledge...
Apr 12, 2026
Full Article View
Salidroside Improves Hyperuricemia by Simultaneously Regulating Uric Acid Production and Excretion
Original Research

Salidroside Improves Hyperuricemia by Simultaneously Regulating Uric Acid Production and Excretion

Shaoshi Zhang, Shun-Dan Li, Dong Chang, Ming‑Yue Wang, Meng‑Fei An, Si-Jia Fu, Ting-Ting Jiang, Jun Sheng, Yun‑Li Zhao, Xuan-Jun Wang
Background: Hyperuricemia is a common metabolic disease, which seriously affects the quality of life of patients. Salidroside (SAL) is a natural phenolic product extracted from Rhodiola rosea root, which is not only less toxic, but also beneficial for metabolic diseases. Purpose: To investigate SAL's role in regulating hyperuricemia and explore the potential mechanism. Methods: Molecular simulation was employed to predict the...
Apr 08, 2026
Full Article View
CMC Challenges and Solutions in Botanical IND & NDA Development
Review

CMC Challenges and Solutions in Botanical IND & NDA Development

Roger Luo
Botanical INDs present unique challenges in chemistry, manufacturing, and controls (CMC) and quality assurance that distinguish them from conventional single-molecule drug development. Over more than two decades, the FDA has progressively constructed a fit-for-purpose regulatory pathway through two successive guidance documents (2004, 2016), the establishment of a dedicated Botanical Review Team within CDER, and the review of hundreds of...
Apr 04, 2026
Full Article Video View
Safety Evaluation of Dendrobium officinale Combined with Black Tea Extract in Rodents
Original Research

Safety Evaluation of Dendrobium officinale Combined with Black Tea Extract in Rodents

Ming-Yue Wang, Guo-Tao Li, Meng-Fei An, Shao-Ying Zhao, Rui Zan, Yu-Ran Xu, Qing-Hong Zi, Yu-Rong Lu, Yan-Xuan Lu, Yun-Li Zhao, Xuan-Jun Wang
Background: Potential acute and chronic oral toxic effects of Dendrobium officinale (DO) and black tea extract (BTE) mixture, a health-care food for osteoporosis, were evaluated to assess its suitability for therapeutic exploitation. Materials & Methods: Acute toxicity was examined via intragastric administration of DO-BTE twice within 24 h at 5 g/kg for a 14-day observation. In the subchronic toxicity test, normal rats were orally...
Mar 25, 2026
Full Article View
CMC Challenges and Solutions in Botanical IND & NDA Development
Review

CMC Challenges and Solutions in Botanical IND & NDA Development

Roger Luo
Botanical INDs present unique challenges in chemistry, manufacturing, and controls (CMC) and quality assurance that distinguish them from conventional single-molecule drug development. Over more than two decades, the FDA has progressively constructed a fit-for-purpose regulatory pathway through two successive guidance documents (2004, 2016), the establishment of a dedicated Botanical Review Team within CDER, and the review of hundreds of...
Apr 04, 2026 564 views
Full Article Video View
Plant-Derived Exosome-Like Nanoparticles: Advances in Therapeutic Applications and Drug Delivery
Review

Plant-Derived Exosome-Like Nanoparticles: Advances in Therapeutic Applications and Drug Delivery

Lu Zhan, Xuqin Huang, Bowen Chang, Qian Li, Li Zhang, Songping Xie, Jie Huang
Background: Plant-derived exosome-like nanoparticles (PELNs) are nanoscale vesicles secreted by plant cells that contain lipids, proteins, RNAs, and secondary metabolites. Increasing evidence indicates that these vesicles can deliver plant-derived molecules into mammalian cells and modulate biological processes, including inflammation, oxidative stress, and immune responses. Scope of the Review: This review summarizes current knowledge...
Apr 12, 2026 479 views
Full Article View
Safety Evaluation of Dendrobium officinale Combined with Black Tea Extract in Rodents
Original Research

Safety Evaluation of Dendrobium officinale Combined with Black Tea Extract in Rodents

Ming-Yue Wang, Guo-Tao Li, Meng-Fei An, Shao-Ying Zhao, Rui Zan, Yu-Ran Xu, Qing-Hong Zi, Yu-Rong Lu, Yan-Xuan Lu, Yun-Li Zhao, Xuan-Jun Wang
Background: Potential acute and chronic oral toxic effects of Dendrobium officinale (DO) and black tea extract (BTE) mixture, a health-care food for osteoporosis, were evaluated to assess its suitability for therapeutic exploitation. Materials & Methods: Acute toxicity was examined via intragastric administration of DO-BTE twice within 24 h at 5 g/kg for a 14-day observation. In the subchronic toxicity test, normal rats were orally...
Mar 25, 2026 335 views
Full Article View
Salidroside Improves Hyperuricemia by Simultaneously Regulating Uric Acid Production and Excretion
Original Research

Salidroside Improves Hyperuricemia by Simultaneously Regulating Uric Acid Production and Excretion

Shaoshi Zhang, Shun-Dan Li, Dong Chang, Ming‑Yue Wang, Meng‑Fei An, Si-Jia Fu, Ting-Ting Jiang, Jun Sheng, Yun‑Li Zhao, Xuan-Jun Wang
Background: Hyperuricemia is a common metabolic disease, which seriously affects the quality of life of patients. Salidroside (SAL) is a natural phenolic product extracted from Rhodiola rosea root, which is not only less toxic, but also beneficial for metabolic diseases. Purpose: To investigate SAL's role in regulating hyperuricemia and explore the potential mechanism. Methods: Molecular simulation was employed to predict the...
Apr 08, 2026 247 views
Full Article View
Rhubarb-Centered Therapy for Intraductal Papillary Mucinous Neoplasm (IPMN): A Case Series and Integrative Medicine Exploration
Case Report

Rhubarb-Centered Therapy for Intraductal Papillary Mucinous Neoplasm (IPMN): A Case Series and Integrative Medicine Exploration

Fan Le, Yufang Xiao, Huifang Brown
Intraductal papillary mucinous neoplasm (IPMN) is an increasingly recognized pancreatic cystic tumor with variable malignant potential. Surgical resection remains the standard treatment for high-risk cases, whereas low-risk patients are typically managed with surveillance. This study presents two clinical cases treated with a rhubarb-centered therapeutic strategy. Both patients demonstrated symptomatic improvement and stable imaging findings....
Apr 15, 2026 203 views
Full Article View
Astragaloside A Attenuates Oxaliplatin-Induced Cardiotoxicity, Oxidative Stress, Apoptosis, and Calcium Overload in H9c2 Cardiomyoblasts
Original Research

Astragaloside A Attenuates Oxaliplatin-Induced Cardiotoxicity, Oxidative Stress, Apoptosis, and Calcium Overload in H9c2 Cardiomyoblasts

Ziheng He, Peng Cao, Wenyu Lin, Guoping Xu, Xueting Cai, Qian Zhou, Yali Liu
Background: Oxaliplatin is a widely used platinum-based chemotherapeutic agent, and its cardiotoxicity remains an important safety concern during cancer treatment. Astragalus -derived saponins have been reported to exert cardioprotective effects; however, the specific active constituent responsible for protecting against oxaliplatin-induced myocardial injury has not been identified. Methods: Several Astragalus saponins and related...
May 15, 2026 203 views
Full Article Presentation Video View
Targeting Apoptotic Pathways in Cancer with Emodin: Intrinsic, Extrinsic, and Caspase-Independent Mechanisms
Review

Targeting Apoptotic Pathways in Cancer with Emodin: Intrinsic, Extrinsic, and Caspase-Independent Mechanisms

Gorky Guha, Shreya Das, Jhansi Kompala, Sohith Reddy Korlagunta, Sukant Khurana, Alfredo Ghezzi, Lakshminarayanan Karthik, Abhijit G Banerjee
Programmed cell death, also known as apoptosis, is crucial for maintaining cellular homeostasis and plays a significant role in tumor development, progression, and resistance to treatment. Evading apoptosis has been a characteristic of cancer, and apoptotic signaling pathways have been proposed as targets of anticancer drug development. Emodin, a naturally occurring anthraquinone produced by medicinal plants, has become a promising...
Jul 05, 2026 157 views
Full Article View

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Botanical Drugs is a peer-reviewed, open-access scientific journal aiming to provide a rigorous, open-access platform for original research, comprehensive reviews, and clinical evidence in the botanical drug industry.

Submission Category: Pharmacology & Mechanism of Action; Toxicology & Safety; Pharmaceutical Analysis (CMC); Pharmacokinetics (ADME); Clinical Study; Regulatory Science.

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